J Pediatr 1993 Dec;123(6):1005-8

Treatment with lenograstim (glycosylated recombinant human granulocyt
colony-stimulating factor) and orthotopic liver transplantation for glycogen
storage disease type Ib

Lachaux A, Boillot O, Stamm D, Canterino I, Dumontet C, Regnier F, Floret D,
Hermier M
Department of Pediatrics, Liver Transplantation Unit, Hopital E. Herriott, Lyon,
France.

Abstract
A 7 1/2-year-old patient with glycogenosis type lb had chronic neutropenia,
recurrent bacterial infections, and severe hypoglycemia in spite of continuous
nasogastric feeding. She was treated with lenograstim (glycosylated recombinant
human granulocyte colony-stimulating factor) and orthotopic liver
transplantation. Absolute neutrophil counts and platelet counts rapidly reached
normal values, and infectious episodes were reduced. She resumed oral feeding
after transplantation and had no subsequent hypoglycemic episodes